• Anaesthesia · Jul 1991

    Randomized Controlled Trial Comparative Study Clinical Trial

    Epidural bupivacaine dilution for labour. A comparison of three concentrations infused with a fixed dose of fentanyl.

    • H A Noble, G R Enever, and T A Thomas.
    • Department of Anaesthesia, Bristol Maternity Hospital.
    • Anaesthesia. 1991 Jul 1;46(7):549-52.

    AbstractWe have compared the effects of three epidural infusions in a randomised, double-blind study of 56 primigravid mothers in labour. An initial dose of bupivacaine 0.5% 8 ml was followed by infusion of either bupivacaine 0.125%, 0.062% or 0.031%. All solutions contained fentanyl 0.0002% and were run at 7.5 ml/hour. Women receiving the most dilute solution had significantly less analgesia (p less than 0.001) for the first 4 hours of the study, but pain scores were then similar for the three groups. No obvious benefit was gained by using very dilute bupivacaine.

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