• Pasquale Berlingieri, Grazina Bogdanskiene, and Jurgis G Grudzinskas.
• Department of Obstetrics and Gynaecology, St. Bartholomew's and The Royal London School of Medicine and Dentistry, London, United Kingdom. p.berlingieri@medsch.ucl.ac.uk <p.berlingieri@medsch.ucl.ac.uk>
• Eur. J. Obstet. Gynecol. Reprod. Biol. 2007 Mar 1;131(1):85-8.

ObjectivesTo evaluate the determinants of tubal rupture in women who suffered from ectopic pregnancy in relation to their demographic profile and medical history.Study DesignThis retrospective observational clinical study was conducted in five general hospitals in Vilnius, Lithuania. The population was composed of 879 women with surgically proven ectopic pregnancy. Tubal rupture was diagnosed at the time of surgery. Univariate and multivariate logistic regression analyses were performed to identify the risk factors for tubal rupture.ResultsThe occurrence of tubal rupture was 29.5% (259/879). It was encountered significantly more often in women with age of > or =35 years (odds ratio 1.9 [1.3-2.8]). Patients whose EP was located in the isthmus were at higher risk of having tubal rupture (odds ratio 3.2 [2.2-4.5]) while known risk factors for EP were not associated with an elevated risk.ConclusionsOur data suggest that age of > or =35 years and implantation in the straightest segment of the tube could be associated with increased rate of tubal rupture. Of particular interest is the overall tubal rupture prevalence (29.5%) observed since these women were managed in an environment where transvaginal ultrasound equipment and quantitative assessment of beta-human chorionic gonadotrophin were not routinely available.

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