• Brigitte A Brouwer, Bianca T A de Greef, Janneke G J Hoeijmakers, Margot Geerts, Maarten van Kleef, Ingemar S J Merkies, and Catharina G Faber.
• Department of Anesthesiology and Pain Medicine, Maastricht University Medical Center, 6202 AZ, Maastricht, The Netherlands.
• Drugs Aging. 2015 Aug 1;32(8):611-21.

AbstractOver the last 10 years, the diagnosis small fiber neuropathy (SFN) has gained recognition worldwide. Patients often suffer from severe neuropathic pain that may be difficult to treat. A substantial subset of patients with SFN is aged 65 years or older, and these patients often exhibit comorbidities and usage of multiple drugs, making neuropathic pain treatment more challenging. In this review, we highlight relevant pathophysiological aspects and discuss currently used therapeutic strategies for neuropathic pain. Possible pitfalls in neuropathic pain treatment in the elderly will be underlined.

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