• Br J Anaesth · Jun 1989

    Randomized Controlled Trial Clinical Trial

    Neurobehavioural effects of propofol on the neonate following elective caesarean section.

    • D Celleno, G Capogna, M Tomassetti, P Costantino, G Di Feo, and R Nisini.
    • Department of Anaesthesia, General Hospital, Rome, Italy.
    • Br J Anaesth. 1989 Jun 1;62(6):649-54.

    AbstractForty mothers undergoing elective Caesarean section under general anaesthesia were allocated randomly to receive either propofol 2.8 mg kg-1 (n = 20) or thiopentone 5 mg kg-1 (n = 20) for induction of anaesthesia. Twenty neonates delivered by uncomplicated vaginal delivery were evaluated also as unmedicated controls. Neurobehavioural examinations were carried out at 1, 4 and 24 h after delivery. Infants in the propofol group had lower Apgar scores at 1 and 5 min; 25% of them had muscular hypotonus at 5 min. This hypotonus was not noted during the Early Neonatal Neurobehavioural Scale (ENNS) examination. Newborn children examined 1 h after birth, after maternal anaesthesia with propofol, showed a depression in alert state, pinprick and placing reflexes, and mean decremental count in Moro and light. There was a generalized irritability in 25% of them. This depression was not observed at 4 h.

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