• CNS Neurosci Ther · Jun 2013

    Review

    Ketamine in pain management.

    • Jan Persson.
    • Department of Anesthesia and Intensive Care, Pain Clinic, Karolinska University Hospital, Stockholm, Sweden. jan.persson@karolinska.se
    • CNS Neurosci Ther. 2013 Jun 1;19(6):396-402.

    AbstractFor ketamine's fiftieth birthday, a narrative review of this unique drug in pain management is presented. Its history is traced from its conception, and its heritage, as a phencyclidine offspring, delineated. The earliest roots of the conceptions concerning the mechanisms of action are sought, and then followed in preclinical as well as clinical research. The major proposed mechanisms in the literature are commented on and evaluated. The growth of the clinical evidence for perioperative pain, acute pain, and chronic pain is followed from early attempts to systematic reviews. Finally, an attempt is made to foresee what the next 50 years might hold in store for our 50 years old.© 2013 John Wiley & Sons Ltd.

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