• Clin. Infect. Dis. · Mar 2013

    Carbapenem-sparing antibiotic regimens for infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae in intensive care unit.

    • Francesco Sbrana, Paolo Malacarne, Bruno Viaggi, Sergio Costanzo, Piero Leonetti, Alessandro Leonildi, Beatrice Casini, Carlo Tascini, and Francesco Menichetti.
    • Fondazione Toscana Gabriele Monasterio, Azienda Ospedaliera Universitaria Pisana, Italy.
    • Clin. Infect. Dis. 2013 Mar 1;56(5):697-700.

    AbstractA carbapenem-sparing regimen of tigecycline plus gentamicin or colistin was effective for treating 24 of 26 (92%) Klebsiella pneumoniae carbapenemase-producing K. pneumoniae infectious episodes in 22 polytrauma intensive care unit patients without comorbidities. The 30-day crude mortality rate was 14%. Regimens were considered appropriate in 12% of episodes according to the Vitek 2 System and in 100% based on E-test.

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