• Michael Ried, Assad Haneya, Philipp Kolat, Tobias Potzger, Thomas Puehler, Cristof Schmid, and Claudius Diez.
• Department of Cardiothoracic Surgery, University Medical Center Regensburg, Regensburg, Germany. micha.ried@t-online.de
• Thorac Cardiovasc Surg. 2012 Feb 1;60(1):51-6.

BackgroundWe tested the hypothesis that octogenarians develop more frequently renal dysfunction compared with septuagenarians after cardiac surgery.MethodsA retrospective, observational study on an age-, gender- and operation-matched cohort of 598 patients, (299 octogenarians vs. 299 septuagenarians) who underwent cardiac surgery between January 2006 and August 2009, was performed. Kidney function was estimated with the abbreviated Modification in Renal Disease equation and acute kidney injury was defined as a decrease of glomerular filtration rate ≥50%.ResultsOperations included 246 coronary, 198 isolated valve, and 154 combined coronary and valve procedures. Mean logistic EuroSCORE was 8.5% in septuagenarians and 13.2% in octogenarians. Octogenarians had significantly more frequent and estimated GFR < 60 mL/min/1.73 m² (44 vs. 34.4%, p = 0.02). The incidence of dialysis-dependent acute kidney failure did not differ between both groups (6.7 vs. 5.4%, p = 0.60). Postoperative decline of glomerular filtration rate <25% occurred significantly more often in septuagenarians (40 vs. 30%, p = 0.02). Septuagenarians with a preoperative GFR < 60 mL/min/1.73 m² had a higher 30-day mortality compared with patients with a GFR > 60 mL/min/1.73 m² (10.9 vs. 3.1%, p = 0.02). Overall, 30-day mortality in octogenarians was 7.7% without significant differences with respect to preoperative GFR.ConclusionsOctogenarians do not develop acute kidney failure more frequently than their matched septuagenarian counterparts. They can be operated on at an acceptable risk for morbidity and mortality. Preoperative impaired renal function is associated with higher risk for mortality in septuagenarians.Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

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