• L S Rasmussen, F Sztuk, M Christiansen, and M J Elliott.
• Department of Anesthesia, Center of Head and Orthopedics, Copenhagen University Hospital, Rigshospitalet, Denmark. lsr@rh.dk
• J. Cardiothorac. Vasc. Anesth. 2001 Oct 1;15(5):563-6.

ObjectiveTo compare normothermic cardiopulmonary bypass (CPB) versus hypothermic CPB in pediatric patients undergoing repair of congenital heart disease with focus on biochemical markers for brain damage.DesignProspective randomized interventional study.SettingPostgraduate teaching hospital.ParticipantsTwenty patients undergoing repair of congenital heart disease.InterventionsPatients were randomized to normothermic (36 degrees C) versus hypothermic (25 degrees C) CPB. Serum levels of neuron-specific enolase (NSE) and S-100beta protein were measured in all patients before surgery, immediately after CPB, and 12 and 24 hours after surgery. Blood loss and time for extubation of the trachea were recorded.Measurements And Main ResultsBefore operation, the S-100beta protein and NSE levels were similar in the 2 groups. The S-100beta protein serum level increased significantly after CPB in both groups, whereas no change was found in the NSE level. There was no difference in the change of NSE and S-100beta protein levels between normothermic and hypothermic CPB. Blood loss was significantly less after hypothermic CPB (25 mL/kg/24 h v 42 mL/kg/24 h). Time for extubation was similar.ConclusionNo difference was found in the release of brain-specific proteins between normothermic and hypothermic CPB, but blood loss was higher after normothermic CPB.Copyright 2001 by W.B. Saunders Company

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