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IEEE Trans Biomed Eng · Sep 2008
Robust predictive control strategy applied for propofol dosing using BIS as a controlled variable during anesthesia.
- Clara M Ionescu, Robin De Keyser, Bismark Claure Torrico, Tom De Smet, Michel M R F Struys, and Julio E Normey-Rico.
- Department of Electrical Energy, Systems and Automation, Ghent University, B9000 Ghent, Belgium. clara@autoctrl.UGent.be
- IEEE Trans Biomed Eng. 2008 Sep 1;55(9):2161-70.
AbstractThis paper presents the application of predictive control to drug dosing during anesthesia in patients undergoing surgery. The performance of a generic predictive control strategy in drug dosing control, with a previously reported anesthesia-specific control algorithm, has been evaluated. The robustness properties of the predictive controller are evaluated with respect to inter- and intrapatient variability. A single-input (propofol) single-output (bispectral index, BIS) model of the patient has been assumed for prediction as well as for simulation. A set of 12 patient models were studied and interpatient variability and disturbances are used to assess robustness of the controller. Furthermore, the controller guarantees the stability in a desired range. The applicability of the predictive controller in a real-life environment via simulation studies has been assessed.
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