• Thoracic surgery clinics · Jan 2015

    Review

    Expanding the donor pool: donation after cardiac death.

    • Haytham Elgharably, Alexis E Shafii, and David P Mason.
    • Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
    • Thorac Surg Clin. 2015 Jan 1;25(1):35-46.

    AbstractLung transplantation (LTx) is the definitive treatment of patients with end-stage lung disease. Availability of donor lungs remains the primary limitation and leads to substantial wait-list mortality. Efforts to expand the donor pool have included a resurgence of interest in the use of donation after cardiac death (DCD) lungs. Unique in its physiology, lung viability seems more tolerant to the variable durations of ischemia that occur in DCD donors. Initial experience with DCD LTx is promising and, in combination with ex vivo lung perfusion systems, seems a valuable opportunity to expand the lung donor pool.

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