• Metabolic brain disease · Dec 2004

    Review

    Hypothermia in acute liver failure.

    • Rajiv Jalan and Christopher Rose.
    • Liver Failure Group, Institute of Hepatology, London, United Kingdom. r.jalan@ucl.ac.uk
    • Metab Brain Dis. 2004 Dec 1;19(3-4):215-21.

    AbstractThe development of encephalopathy in patients with acute liver injury defines the occurrence of liver failure. The encephalopathy of acute liver failure is characterized by brain edema which manifests clinically as increased intracranial pressure. Despite the best available medical therapies a significant proportion of patients with acute liver failure die due to brain herniation. The present review explores the experimental and clinical data to define the role of hypothermia as a treatment modality for increased intracranial pressure in patients with acute liver failure.

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