• Connecticut medicine · Aug 1999

    Case Reports

    Rhabdomyolysis associated with the combined use of hydroxymethylglutaryl-coenzyme A reductase inhibitors with gemfibrozil and macrolide antibiotics.

    • K A Landesman, M Stozek, and N J Freeman.
    • Brown University School of Medicine, Internal Medicine Residency Program Providence, Rhode Island, USA.
    • Conn Med. 1999 Aug 1;63(8):455-7.

    AbstractThe hydroxymethylglutaryl-coenzyme A reductase inhibitors (HMG-CoAs) are one of the most significant causes of medication induced rhabdomyolysis. The development of rhabdomyolysis is increased when the HMG-CoAs are used concurrently with certain other medications, specifically gemfibrozil and macrolide antibiotics. In this report, we describe a patient with rhabdomyolysis from the combined use of lovastatin, gemfibrozil, and clarithromycin and review the relevant literature.

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