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Ugeskrift for laeger · Feb 2001
Review[Surgical physiopathology. New results of importance for optimization of the postoperative course].
- J Rosenberg and H Kehlet.
- H:S Hvidovre Hospital, kirurgisk sektion, gastroenheden.
- Ugeskr. Laeg. 2001 Feb 12;163(7):908-12.
AbstractComplications after major surgery may be related to factors in the surgical stress response with endocrine-metabolic and inflammatory changes. In order to prevent these complications, it is important to understand the stress reaction of each organ system. The inflammatory response may be partly prevented by a minimal invasive surgical technique or by preoperative administration of high-dose steroids. Prevention of the endocrine-metabolic changes is best achieved with neural blockade. Unimodal intervention cannot eliminate morbidity and mortality after major surgery. Thus, multi-modal intervention with attenuation of the surgical stress response, effective dynamic treatment of pain, enforced mobilisation, and nutrition should be employed when possible.
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