• Anesthesia progress · Jan 1999

    Randomized Controlled Trial Clinical Trial

    Clinical effectiveness of lidocaine and benzocaine for topical anesthesia.

    • A L Rosa, C E Sverzut, S P Xavier, and M A Lavrador.
    • Department of Oral and Maxillofacial Surgery and Periodontology, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, Brazil. adalrosa@forp.usp.br
    • Anesth Prog. 1999 Jan 1;46(3):97-9.

    AbstractThe effectiveness of lidocaine and benzocaine in reducing pain produced by needle insertion into the palate was evaluated in a double-blind and placebo-controlled study using a more suitable method. Twenty subjects, 10 men and 10 women, submitted to 4 sessions in which they were randomly treated with 5% lidocaine, a placebo that tasted like lidocaine, 20% benzocaine, and a placebo that tasted like benzocaine. At each session, a 27-gauge needle was inserted into the palate twice, once before (baseline) and once after drug application for 1 minute. Immediately after each insertion, subjects indicated on a visual analog scale the pain intensity perceived. Lidocaine and benzocaine were equally efficient, and both were better than placebo in reducing pain caused by insertion of needles into the palate.

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