• Tuomas Liikavainio, Tarja Lyytinen, Erja Tyrväinen, Sarianna Sipilä, and Jari P Arokoski.
• Department of Physical and Rehabilitation Medicine, Kuopio University Hospital, Kuopio, Finland; Kolari Health Centre, Kolari, Finland. liikavai@hytti.uku.fi
• Arch Phys Med Rehabil. 2008 Nov 1;89(11):2185-94.

ObjectivesTo examine the objective physical function of the lower extremities, to measure the properties of quadriceps femoris muscle (QFM), and to assess subjective disabilities in men with knee osteoarthritis (OA) and to compare the results with those obtained from age- and sex-matched control subjects.DesignCross-sectional study.SettingRehabilitation clinic in a university hospital.ParticipantsMale volunteers (n=54) (age range, 50-69y) with knee OA and randomly selected healthy, age- and sex-matched control subjects (n=53).InterventionsNot applicable.Main Outcome MeasuresPhysical function evaluated with a test battery including the QFM composition measurement, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the RAND 36-Item Short-Form Health Survey, version 1.0.ResultsKnee OA patients had 13% to 26% poorer (P range, .050-.001) physical function and muscle strength compared with the controls. There were also significant differences in QFM composition. WOMAC (P range, .050-.001) and muscle strength (P<.001) associated with physical function tests, but subjective pain correlated with neither physical function nor muscle strength in knee OA patients. The radiographic knee OA grade did not have any significant effect on physical function, but passive knee motion, knee extension strength, and WOMAC were related to the severity of the disease (P<.05).ConclusionsThe patients with knee OA exhibited impaired physical function and muscle strength and QFM composition compared with healthy controls. The severity of radiographic knee OA clearly had adverse effects on functional ability at the later stages of the disease. The results highlight the effect of QFM strength on physical function as well as the importance of patient's subjective and objective physical function when deciding on knee OA treatment policy.

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