• Anaesthesia · Jun 1994

    Randomized Controlled Trial Comparative Study Clinical Trial

    An investigation of the local anaesthetic effects of pethidine in volunteers.

    • G J Oldroyd, E J Tham, and I Power.
    • Department of Anaesthetics, University of Wales College of Medicine, Heath Park, Cardiff.
    • Anaesthesia. 1994 Jun 1;49(6):503-6.

    AbstractWe have investigated the local anaesthetic effects of 0.1% and 0.2% pethidine compared with 0.5% prilocaine using an intravenous regional anaesthetic technique, in a randomised, double-blind study in volunteers. Both pethidine and prilocaine produced a sensory and motor blockade, although the latter had a more profound effect, with a faster onset and slower recovery. Pethidine in low concentration clearly has a local anaesthetic action on peripheral nerves.

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