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Clin. Microbiol. Infect. · May 2012
The use of rpoB sequence analysis in the differentiation of Mycobacterium abscessus and Mycobacterium chelonae: a critical judgement in cystic fibrosis?
- C Arnold, A Barrett, L Cross, and J G Magee.
- Applied and Functional Genomics Unit, HPA Microbiology Services, Centre for Infections, London, UK.
- Clin. Microbiol. Infect. 2012 May 1;18(5):E131-3.
AbstractIndividuals suffering from fibrocystic disease may acquire non-tuberculous mycobacteria as colonizing or infecting organisms. Mycobacterium abscessus is of particular concern because it may be very difficult to eradicate and may mitigate against lung transplantation. However, this species may be difficult to reliably differentiate from the closely related M. chelonae. We have developed a rapid, low-cost, short sequence-based technique to confirm species identity by analysis of a segment of the RNA Polymerase B (rpoB) gene.© 2012 The Authors. Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases.
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