• Peter B Hjortrup, Nicolai Haase, Jørn Wetterslev, and Anders Perner.
• Department of Intensive Care, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. peter.buhl.hjortrup@regionh.dk.
• Crit Care Resusc. 2016 Mar 1;18(1):55-8.

ObjectiveTo maximise the yield of existing data by assessing the effect on mortality of being born under the zodiac sign Pisces in a trial of intravenous (IV) fluids.Design, Setting And ParticipantsA retrospective observational study, with no predefined hypothesis or statistical analysis plan, of 26 Scandinavian intensive care units between 2009 and 2011. Patients aged 18 years or older with severe sepsis and in need of fluid resuscitation, randomised in the Scandinavian Starch for Severe Sepsis/ Septic Shock (6S) trial.Main Outcome MeasureNinety-day mortality.ResultsWe included all 798 randomised patients in our study; 70 (9%) were born under the sign of Pisces. The primary outcome (death within 90 days after randomisation) occurred in 25 patients (35.7%) in the Pisces group, compared with 348 patients (48%) in the non-Pisces group (relative risk, 0.75; 95% CI, 0.54-1.03; one-sided P = 0.03).ConclusionsIn a multicentre randomised clinical trial of IV fluids, being born under the sign of Pisces was associated with a decreased risk of death. Our study shows that with convenient use of statistics and an enticing explanatory hypothesis, it is possible to achieve significant findings in post-hoc analyses of data from large trials.

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