• Neurosurgery · Dec 1989

    Case Reports

    Fatal phenytoin-related toxic epidermal necrolysis: case report.

    • D F Kelly and D G Hope.
    • Department of Neurosurgery, George Washington University School of Medicine, Washington, District of Columbia.
    • Neurosurgery. 1989 Dec 1;25(6):976-8.

    AbstractToxic epidermal necrolysis is a rare but often fatal hypersensitivity reaction to numerous agents, including most anticonvulsants. The authors present a case of fatal phenytoin-related toxic epidermal necrolysis in a patient who was given prophylactic anticonvulsant therapy after he sustained a moderately severe closed head injury. The typical course and current management of toxic epidermal necrolysis are reviewed, as are the indications for the prophylaxis of posttraumatic epilepsy.

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