• Intensive care medicine · Jan 1990

    Randomized Controlled Trial Clinical Trial

    Plasma catecholamine concentration during sedation in ventilated patients requiring intensive therapy.

    • K L Kong, S M Willatts, C Prys-Roberts, J T Harvey, and S Gorman.
    • Sir Humphrey Davy Department of Anaesthesia, Bristol Royal Infirmary, UK.
    • Intensive Care Med. 1990 Jan 1;16(3):171-4.

    AbstractThe effects of isoflurane and midazolam sedation on the catecholamine responses of ventilated patients were studied over a 24-h period. Sixty ventilated patients admitted to our intensive therapy unit were allocated randomly to receive either isoflurane or midazolam sedation. Arterial blood samples for plasma catecholamine concentrations were taken at baseline, 6 h after starting sedation and at the end of the study period. Patients sedated with isoflurane showed a progressive reduction in both adrenaline and noradrenaline concentrations during the period of sedation which reached statistical significance for adrenaline at 6 h (p less than 0.02) and at the end of the study (p less than 0.001). Patients sedated with midazolam showed no significant changes of adrenaline or noradrenaline concentrations. Overall, a more satisfactory degree of sedation was achieved with isoflurane.

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