• Masataka Eto, Shigeki Morita, Masakazu Sugiura, Tetsuji Yoshimura, Ryuji Tominaga, and Takehisa Matsuda.
• Division of Cardiovascular Surgery, Graduate School of Medical Science, Kyushu University, Fukuoka 812-8582, Japan.
• Eur J Cardiothorac Surg. 2007 Nov 1;32(5):730-4.

PurposeWe developed a novel surgical sealant, a viscous diisocyanated prepolymer, applicable to arterial hemostasis. The purpose of this study is to evaluate hemostatic effect of this surgical sealant under heparinized conditions.MethodsThe effectiveness of this sealant was verified by applying it to the end-to-end anastomosis of canine carotid arteries. Five mongrel dogs were used. After a complete heparinization, the carotid arteries were clamped, divided, and end-to-end anastomoses were performed with four simple interrupted sutures. The sealant was coated on the anastomosis. After 5 min the clamps were removed and the hemostatic effect was evaluated. Three dogs were immediately subjected to macroscopic evaluation. Two dogs were subjected to angiography after 3 months and 16 months, respectively.ResultsNo bleeding occurred in any of the anastomoses immediately after the removal of the clamp. Macroscopic finding revealed no leakage of the sealant into the lumen. Carotid angiography revealed patent anastomoses without stenosis.ConclusionA novel surgical sealant exhibited rapid and potent hemostatic effect on a moisturized tissue under full heparinization.

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