• Chin. J. Traumatol. · Dec 2003

    Randomized Controlled Trial Comparative Study Clinical Trial

    Cerebral perfusion SPECT imaging for assessment of the effect of hyperbaric oxygen therapy on patients with postbrain injury neural status.

    • Xiao-yan Shi, Zhong-quan Tang, Bing Xiong, Jian-xiu Bao, Da Sun, Yun-qiu Zhang, and Yu Yao.
    • The 2nd Hospital Affiliated to Medical College of Zhejiang University, Hangzhou 310009, China. jzyx@mail.hz.zj.cn
    • Chin. J. Traumatol. 2003 Dec 1;6(6):346-9.

    ObjectiveTo evaluate the effects of hyperbaric oxygen (HBO) therapy on patients with postbrain injury neural status.MethodsTwo to 4 courses of HBO therapy and/or medications were used to treat 320 patients who were randomly divided into two groups. Assessment was made with (99m)Tc-ethyl cysteinate dimer ( (99m)Tc-ECD) single photon emission computed tomography (SPECT) before and after treatment.ResultsThere was a significant difference between the HBO therapy group and the non-HBO therapy group. HBO therapy was superior to medication treatment alone in the recovery of clinical symptoms, control of epilepsy, and resolution of hydrocephalus (P<0.01).ConclusionsHBO therapy has specific curative effects on patients with postbrain injury neural status, and (99m)Tc-ECD SPECT could play an important role in diagnosing postbrain injury neural status and monitoring the therapeutic effects of HBO.

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