• Blood · Jul 2012

    Review

    Red blood cell alloimmunization in sickle cell disease: pathophysiology, risk factors, and transfusion management.

    • Karina Yazdanbakhsh, Russell E Ware, and France Noizat-Pirenne.
    • Laboratory of Complement Biology, New York Blood Center, 310 East 67th St, NewYork, NY 10065, USA. kyazdanbakhsh@nybloodcenter.org
    • Blood. 2012 Jul 19;120(3):528-37.

    AbstractRed blood cell transfusions have reduced morbidity and mortality for patients with sickle cell disease. Transfusions can lead to erythrocyte alloimmunization, however, with serious complications for the patient including life-threatening delayed hemolytic transfusion reactions and difficulty in finding compatible units, which can cause transfusion delays. In this review, we discuss the risk factors associated with alloimmunization with emphasis on possible mechanisms that can trigger delayed hemolytic transfusion reactions in sickle cell disease, and we describe the challenges in transfusion management of these patients, including opportunities and emerging approaches for minimizing this life-threatening complication.

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