• J C Montejo, E Miñambres, L Bordejé, A Mesejo, J Acosta, A Heras, M Ferré, F Fernandez-Ortega, C I Vaquerizo, and R Manzanedo.
• Medicina Intensiva, Unidad Polivalente, ICU, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain. jmontejo.hdoc@salud.madrid.org
• Intensive Care Med. 2010 Aug 1; 36 (8): 1386-93.

ObjectiveTo compare the effects of increasing the limit for gastric residual volume (GRV) in the adequacy of enteral nutrition. Frequency of gastrointestinal complications and outcome variables were secondary goals.DesignAn open, prospective, randomized study.SettingTwenty-eight intensive care units in Spain.PatientsThree hundred twenty-nine intubated and mechanically ventilated adult patients with enteral nutrition (EN).InterventionsEN was administered by nasogastric tube. A protocol for management of EN-related gastrointestinal complications was used. Patients were randomized to be included in a control (GRV = 200 ml) or in study group (GRV = 500 ml).Measurements And ResultsDiet volume ratio (diet received/diet prescribed), incidence of gastrointestinal complications, ICU-acquired pneumonia, days on mechanical ventilation and ICU length of stay were the study variables. Gastrointestinal complications were higher in the control group (63.6 vs. 47.8%, P = 0.004), but the only difference was in the frequency of high GRV (42.4 vs. 26.8%, P = 0.003). The diet volume ratio was higher for the study group only during the 1st week (84.48 vs. 88.20%) (P = 0.0002). Volume ratio was similar for both groups in weeks 3 and 4. Duration of mechanical ventilation, ICU length of stay or frequency of pneumonia were similar.ConclusionsDiet volume ratio of mechanically ventilated patients treated with enteral nutrition is not affected by increasing the limit in GRV. A limit of 500 ml is not associated with adverse effects in gastrointestinal complications or in outcome variables. A value of 500 ml can be equally recommended as a normal limit for GRV.

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