-
Curr Opin Clin Nutr Metab Care · Sep 2006
ReviewGlutamine: role in gut protection in critical illness.
- Paul E Wischmeyer.
- Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA. Paul.Wischmeyer@UCHSC.edu
- Curr Opin Clin Nutr Metab Care. 2006 Sep 1;9(5):607-12.
Purpose Of ReviewRecent literature has focused on the role of the gut and increased gut permeability as a driver of systemic inflammation in critical illness. Thus, the therapeutic potential for an agent to prevent gut barrier compromise and attenuate gut-derived inflammatory response is significant.Recent FindingsIn laboratory and clinical settings, glutamine can attenuate gut permeability following critical illness and injury. Further, recent literature has revealed other mechanisms by which glutamine may attenuate the systemic inflammatory response driven by the gut. These findings reveal that glutamine may act at multiple levels to attenuate gut injury and potential subsequent gut-derived systemic inflammatory response. These mechanisms focus around glutamine's ability to induce the cellular protective stress response in the gut. This leads to enhanced protection of the gut epithelial barrier and attenuation of generation of inflammatory mediators.SummaryThese mechanistic findings, combined with a limited amount of clinical data showing benefit on gut permeability in illness and injury, indicate more formal studies need to be carried out looking the role of glutamine in gut protection and as an antiinflammatory in critical illness.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*
,_underline_
or**bold**
. - Superscript can be denoted by
<sup>text</sup>
and subscript<sub>text</sub>
. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3.
, hyphens-
or asterisks*
. - Links can be included with:
[my link to pubmed](http://pubmed.com)
- Images can be included with:
![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
- For footnotes use
[^1](This is a footnote.)
inline. - Or use an inline reference
[^1]
to refer to a longer footnote elseweher in the document[^1]: This is a long footnote.
.