• Intensive care medicine · Dec 2000

    Review

    Intravenous amiodarone in intensive care. Time for a reappraisal?

    • M Hughes and A Binning.
    • Department of Anaesthetics, Royal Infirmary, Glasgow, Scotland. mh4493@compuserve.com
    • Intensive Care Med. 2000 Dec 1;26(12):1730-9.

    AbstractAmiodarone is widely used in intensive care units for the treatment of a variety of arrhythmias. It is currently the drug of choice for supraventricular tachyarrhythmias in many units because of its combination of efficacy and safety. This review summarises the current state of knowledge regarding the short-term administration of intravenous amiodarone to control arrhythmias in perioperative, coronary care and intensive care patients. It outlines the electrophysiology, haemodynamics, pharmacokinetics and toxicity of the drug. In particular, it examines the recent concerns regarding acute pulmonary toxicity.

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