• Ulus Travma Acil Cer · May 2014

    The effect of hyperbaric oxygen therapy on fracture healing in nicotinized rats.

    • Abdullah Demirtaş, Ibrahim Azboy, Mehmet Bulut, Bekir Yavuz Uçar, Celil Alemdar, Ulaş Alabalık, Veysi Akpolat, Ismail Yıldız, and Savaş Ilgezdi.
    • Department of Orthopaedics and Traumatology, Dicle University Faculty of Medicine, Diyarbakır, Turkey. abdullah_demirtas@yahoo.com.
    • Ulus Travma Acil Cer. 2014 May 1;20(3):161-6.

    BackgroundThe aim of the present study was to investigate the effect of hyperbaric oxygen therapy on fracture healing in nicotinized rats.MethodsThirty-two rats were divided as follows: nicotinized group (1), hyperbaric oxygen group (2), nicotinized + hyperbaric oxygen group (3), and control group (4). For 28 days, nicotine was administered in Groups 1 and 3. Then, a standard shaft fracture was induced in the left femur of rats. Groups 2 and 3 underwent hyperbaric oxygen therapy for 21 days. At the end of the experiment, fracture site, left femur and whole body bone mineral content and density were measured.ResultsThe radiological and histopathological scores of Group 1 were statistically significantly lower compared to Groups 2, 3 and 4, and there was no statistically significant difference between the Groups 2, 3 and 4. In a comparison between the groups, no statistically significant difference was found in terms of bone mineral content and density values measured at the fracture site, left femur and whole body.ConclusionThe negative effects of nicotine on fracture healing are eliminated with hyperbaric oxygen therapy, but hyperbaric oxygen alone does not cause significant changes in healing (radiologically and histopathologically).

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