• Yoon-Ji Choi, Sang-Wook Park, Hyun-Jung Kwon, Jae-Moon Choi, and Yu-Mi Lee.
• Department of Dental Anaesthesiology, Seoul National University Dental Hospital, Seoul, Republic of Korea.
• J. Int. Med. Res. 2015 Dec 1; 43 (6): 809-18.

ObjectivesTo compare prospectively the efficacy of early intravenous bolus of oxycodone or fentanyl in providing analgesia at emergence from general anaesthesia following laparoscopic cholecystectomy.MethodsPatients were randomly assigned to receive either 0.08 mg/kg oxycodone (Group O) or 1 µg/kg fentanyl (Group F), 20 min before the end of surgery. Postoperative pain was evaluated using a visual analogue scale (VAS). The time to first postoperative analgesic dose, requirement for analgesia and side-effects were assessed in the postanaesthesia care unit (PACU).ResultsThe VAS scores at 0 min and 30 min and requirement for analgesia were significantly lower in Group O (n = 28) than in Group F (n = 26). The time to first analgesia dose was significantly longer in Group O than Group F. There were no significant between-group differences in the incidence of side-effects.ConclusionsOxycodone relieves immediate postoperative pain significantly better than fentanyl, and is not associated with an increase in side-effects in patients undergoing laparoscopic cholecystectomy.© The Author(s) 2015.

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