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- Celest M Austin, Xin Ma, and Edward A Graviss.
- Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA.
- J. Infect. Dis. 2008 Jun 15;197(12):1713-6.
AbstractPattern-recognition receptors (PRRs) play a key role in innate immunity against intracellular bacteria. NOD2 is one of the PRRs that contribute to the immune response to Mycobacterium tuberculosis infection. We sequenced coding regions of the NOD2 gene in 377 African Americans with tuberculosis (TB) disease and 187 ethnically matched control subjects. Three common nonsynonymous single-nucleotide polymorphisms--Pro268Ser, Arg702Trp, and Ala725Gly--demonstrated significant associations with TB disease. This finding may contribute to the future development of immunotherapy and immunoprophylaxis for TB disease.
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