• Critical care clinics · Jan 2009

    Historical Article

    Sepsis and septic shock: a history.

    • Duane J Funk, Joseph E Parrillo, and Anand Kumar.
    • Anesthesiology and Critical Care, University of Manitoba, Manitoba, Canada.
    • Crit Care Clin. 2009 Jan 1;25(1):83-101, viii.

    AbstractInfectious disease has been a leading cause of death in humans since the first recorded tabulations. From Hippocrates and Galen, to Lister, Fleming and Semmelweiss, this article reviews the notable historical figures of sepsis research. The early descriptions and theories about the etiology (microbial pathogens), pathogenesis (toxins and mediators), and treatment of sepsis-associated disease are also discussed.

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