• Anesthesiology clinics · Dec 2014

    Review

    Perioperative management of the opioid tolerant patient for orthopedic surgery.

    • Marchyarn Mahathanaruk, James Hitt, and Oscar A de LeonCasasola.
    • University at Buffalo Department of Anesthesiology, 252 Farber Hall, 3435 Main Street, Buffalo, NY 14214, USA.
    • Anesthesiol Clin. 2014 Dec 1;32(4):923-32.

    AbstractThe prevalence of opioid use in the North America and some countries of the European Union has resulted in an increase in the number of patients who may exhibit opioid tolerance when requiring postoperative pain management. The approach to postoperative pain control in these patients is different from the strategies used in opioid-naïve patients. Better understanding of the cellular mechanisms of opioid tolerance in animals has resulted in the transfer of these concepts from the basic research to the clinical arena. This article presents new developments in opioid tolerance and how this knowledge can be applied to clinical practice.Copyright © 2014 Elsevier Inc. All rights reserved.

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