• Masahiro Sogabe, Yoshitaka Kimura, Hiroshi Iwaki, Yoshio Okita, Shingo Hibino, Seizo Sawda, Toshiya Okahisa, Koichi Okamoto, Koji Tsujigami, Hiroshige Hayashi, Yasuo Hukui, Toshio Nakamura, Toshikatsu Taniki, Masahiko Nakasono, Naoki Muguruma, Seisuke Okamura, and Susumu Ito.
• Department of Digestive and Cardiovascular Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima, Japan.
• J. Gastroenterol. Hepatol. 2008 Jul 1;23(7 Pt 2):e17-22.

Background And AimsDiabetic patients with poor glycemic control or long standing disease often have impaired gastric motility. Recently, metabolic factors such as blood glucose have been reported as influencing gastric motility independently of autonomic neuropathy. Many diabetic patients have metabolic syndrome, which is strongly associated with coronary and other diseases. We investigated whether metabolic syndrome influences diabetic gastroparesis patients.MethodsWe observed gastric motility ultrasonographically in diabetic gastroparesis patients including nine with and nine without metabolic syndrome. Both groups complained of upper abdominal symptoms when hospitalized to improve blood sugar control. All patients underwent upper gastrointestinal endoscopy to rule out gastric and duodenal lesions. All had autonomic neuropathy. Gastric motility was evaluated within 3 days after admission by transabdominal ultrasonography after a test meal.ResultsGastric emptying was 45.0 +/- 13.7% in patients with and 39.1 +/- 11.9% in patients without metabolic syndrome, which was not statistically significant. Frequency of gastric contractions was 8.33 +/- 2.78 per 3 min in patients with metabolic syndrome and 7.44 +/- 2.13 per 3 min in the others, which was not statistically significant. The motility index, which involves antral contractility, was 3.21 +/- 2.18 in patients with metabolic syndrome and 2.80 +/- 1.87 in the others, which was not statistically significant.ConclusionsMetabolic syndrome did not appear to contribute to delayed gastric motility in diabetic gastroparesis.

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