• Jun-song Wu, Lei Sheng, Yue-feng Ma, Shen-hua Wang, Wen Zhou, Jin-ming Chen, Mao Zhang, Shao-wen Xu, and Guan-yu Jiang.
• Emergency Department, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. wjs128@sohu.com
• Zhonghua Yi Xue Za Zhi. 2009 Jun 16;89(23):1602-6.

ObjectivesTo investigate the potential risk factors of affecting progression from acute lung injury (ALI) to acute respiratory distress syndrome in severe trauma population.MethodsTwenty potential risk factors of affecting progression of acute lung injury were examined by univariate and multivariate logistic analyses among the severe trauma patients in a retrospective study.ResultsAll of 375 specially severe trauma patients with ALI were included for analysis. The six risk factors that affected the progression from acute lung injury to acute respiratory distress syndrome were sepsis, duration of trauma, APACHE II score, DIC, aspiration of gastric contents, and advanced age. Specific risk factors also affected different patient subpopulations at different degrees.ConclusionImpact of sepsis, DIC and duration of trauma that predict progression of ALI exists throughout the entire treatment period while aspiration of gastric contents and APACHE II score might affect aggravation of ALI only during the early period; due to deterioration of pulmonary function and severely traumatic injury, advanced age is still an independent risk factor; patients with these risk factors need aggressive supportive cares as early as possible in order to prevent further aggravations.

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