• Stephen W Rothwell, James M Fudge, Wan-Keung Chen, Thomas J Reid, and Chitra Krishnamurti.
• Department of Blood Research, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA. stephen.rothwell@na.amedd.army.mil
• Thromb. Res. 2002 Dec 15;108(5-6):335-40.

AbstractFibrin bandages manufactured by Nycomed Austria (TC-S) were modified by the addition of Hemostyptin (HS), a proprietary platelet-activating reagent containing propyl gallate. HS was added as an additional layer to TC-S fibrin bandages and the bandages were tested for hemostatic efficacy in a swine femoral artery bleeding model. Injuries were treated with a TC-S+HS bandage preparation using HS lyophilized onto a bandage surface that was then attached to the fibrin dressing. This preparation qualitatively and quantitatively exhibited more robust blood clotting at the surgical site than the control bandages. TC-S+HS bandages were more effective than control bandages with a difference in blood loss of 251.8+/-66.5 g for TC-S bandage alone, n=12 vs. 121+/-40.7 g, n=13 for the TC-S+HS bandage, P=0.05. Bleeding times were shortened for animals treated with the HS fortified bandages and residual platelets counts in these animals were higher.

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