• A & A case reports · Oct 2015

    Case Reports

    Methylene Blue for Vasoplegia When on Cardiopulmonary Bypass During Double-Lung Transplantation.

    • Michelle Carley, Jacob Schaff, Terrance Lai, and Jeremy Poppers.
    • From the Department of Anesthesiology, NYP - Columbia University Medical Center, New York, New York.
    • A A Case Rep. 2015 Oct 15; 5 (8): 127-30.

    AbstractVasoplegia syndrome, characterized by hypotension refractory to fluid resuscitation or high-dose vasopressors, low systemic vascular resistance, and normal-to-increased cardiac index, is associated with increased morbidity and mortality after cardiothoracic surgery. Methylene blue inhibits inducible nitric oxide synthase and guanylyl cyclase, and has been used to treat vasoplegia during cardiopulmonary bypass. However, because methylene blue is associated with increased pulmonary vascular resistance, its use in patients undergoing lung transplantion has been limited. Herein, we report the use of methylene blue to treat refractory vasoplegia during cardiopulmonary bypass in a patient undergoing double-lung transplantation.

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