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Curr Opin Anaesthesiol · Jun 2010
ReviewCan inhalation agents be used in the presence of a child with myopathy?
- Francis Veyckemans.
- Anesthesiology, Cliniques universitaires St Luc, Catholic University of Louvain Medical School, Brussels, Belgium. francis.veyckemans@uclouvain.be
- Curr Opin Anaesthesiol. 2010 Jun 1;23(3):348-55.
Purpose Of ReviewAnaesthesia for a child with a muscle disease is always challenging because there is a risk of malignant hyperthermia, rhabdomyolysis or hypermetabolic reaction if a halogenated agent is used. Ongoing progress in genetics helps in clarifying the link between malignant hyperthermia (a calcium channelopathy) and muscle diseases.Recent FindingsWe provide a summary of the most recent clinical, pathophysiological and genetic information on those risks when the diagnosis is known or suspected preoperatively. Some simple clues are also given to help make a decision in the presence of an infant or child with hypotonia or motor delay but no diagnosis.SummaryOnly a few muscle diseases are really associated with a risk of malignant hyperthermia. The risk of rhabdomyolysis is more difficult to clarify and a multicentric database would be useful to evaluate the risk/benefit ratio of all anaesthetic drugs in patients with muscle diseases.
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