• Nature medicine · Jul 1998

    Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury.

    • C Woiciechowsky, K Asadullah, D Nestler, B Eberhardt, C Platzer, B Schöning, F Glöckner, W R Lanksch, H D Volk, and W D Döcke.
    • Department of Neurosurgery, Medical School Charité, Humboldt University, Berlin, Germany.
    • Nat. Med. 1998 Jul 1;4(7):808-13.

    AbstractThe mechanism of immunodepression after brain injury is not yet clear. Here we demonstrate rapid systemic release of the immunoinhibitory cytokine interleukin-10, monocytic deactivation and a high incidence of infection in patients with 'sympathetic storm' due to acute accidental or iatrogenic brain trauma. In vitro studies showed that within minutes catecholamines trigger the secretion of interleukin-10 from unstimulated monocytes through a beta-adrenoreceptor-mediated, cAMP/protein kinase A-dependent pathway. We found that in a rat model of acute brain injury, the beta-receptor antagonist propranolol prevented the increase of interleukin-10 plasma levels. Rapid monocytic interleukin-10 release after sympathetic activation may represent a common pathway for immunodepression induced by stress and injury.

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