• Timothy S Walsh, Kirsty Everingham, Fiona Frame, T Petteri Lapinlampi, Mika O K Särkelä, Kimmo Uutela, and Hanna E Viertiö-Oja.
• Centre for Inflammation Research, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, Scotland. Electronic address: twalsh@staffmail.ed.ac.uk.
• J Crit Care. 2014 Oct 1; 29 (5): 886.e1-7.

PurposeThe purpose of this study is to explore the validity of a novel sedation monitoring technology based on facial electromyelography (EMG) in sedated critically ill patients.Materials And MethodsThe Responsiveness Index (RI) integrates the preceding 60 minutes of facial EMG data. An existing data set was used to derive traffic light cut-offs for low (red), intermediate (amber), and higher (green) states of patient arousal. The validity of these was prospectively evaluated in 30 sedated critically ill patients against hourly Richmond Agitation Sedation Scale (RASS) assessments with concealment of RI data from clinical staff.ResultsWith derivation data, an RI less than or equal to 35 had best discrimination for a Ramsay score of 5/6 (sensitivity, 90%; specificity, 79%). For traffic lights, we chose RI less than or equal to 20 as red, 20 to 40 as amber, and more than 40 as green. In the prospective study, RI values were red/amber for 76% of RASS -5/-4 assessments, but RI varied dynamically over time in many patients, and discordance with RASS may have resulted from the use of 1 hour of data for RI calculations. We also noted that red/amber values resulted from sleep, encephalopathy, and low levels of stimulation.ConclusionsResponsiveness Index is not directly comparable with clinical sedation scores but is a potential continuous alert to possible deep sedation in critically ill patients.Copyright © 2014 Elsevier Inc. All rights reserved.

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