• Metab. Clin. Exp. · Mar 2011

    Visceral fat decreased by long-term interdisciplinary lifestyle therapy correlated positively with interleukin-6 and tumor necrosis factor-α and negatively with adiponectin levels in obese adolescents.

    • Fábio Santos Lira, Jose Cesar Rosa, Ronaldo Vagner Dos Santos, Daniel Paulino Venancio, June Carnier, Priscila de Lima Sanches, Claudia Maria Oller do Nascimento, Aline de Piano, Lian Tock, Sergio Tufik, Marco Túlio de Mello, Ana R Dâmaso, and Lila Missae Oyama.
    • Postgraduate Program of Nutrition, Federal University of São Paulo-UNIFESP, São Paulo/SP 04020-060, Brazil. fabioslira@gmail.com
    • Metab. Clin. Exp. 2011 Mar 1;60(3):359-65.

    AbstractThe purpose of this study was to assess the level of cytokine expression in correlation with visceral and subcutaneous fat in obese adolescents admitted to long-term interdisciplinary weight loss therapy. The study was a longitudinal clinical intervention of interdisciplinary therapy. Adolescents (18, aged 15-19 years) with body mass indexes greater than the 95th percentile were admitted and evaluated at baseline and again after 1 year of interdisciplinary therapy. Visceral and subcutaneous fat was analyzed by ultrasonography. Blood samples were collected to analyze tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-10 (IL-10), and adiponectin concentrations that were measured by enzyme-linked immunosorbent assay. The most important finding in the present investigation is that the long-term interdisciplinary lifestyle therapy decreased visceral fat. Positive correlations between IL-6 levels and visceral fat (r = 0.42, P < .02) and TNF-α levels and visceral fat (r = 0.40, P < .05) were observed. Negative correlations between TNF-α levels and subcutaneous fat (r = -0.46, P < .01) and adiponectin levels and subcutaneous fat (r = -0.43, P < .03) were also observed. In addition, we found a positive correlation between TNF-α levels and the visceral to subcutaneous fat ratio (r = 0.42, P < .02) and a negative correlation between adiponectin level and the visceral to subcutaneous fat ratio (r = -0.69, P < .001). Despite the limitation of sample size, our results indicate that the observed massive weight loss (mainly visceral fat) was highly correlated with a decreased inflammatory state, suggesting that the interdisciplinary therapy was effective in decreasing inflammatory markers.Copyright © 2011 Elsevier Inc. All rights reserved.

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