• Thierry Le Tourneau, Marjorie Richardson, Francis Juthier, Thomas Modine, Georges Fayad, Anne-Sophie Polge, Pierre-Vladimir Ennezat, Christophe Bauters, André Vincentelli, and Ghislaine Deklunder.
• Inserm, UMR 915, Institut du Thorax, Nantes, France. thletourneau@yahoo.fr
• Heart. 2010 Aug 1;96(16):1311-7.

ObjectiveTo evaluate the predictors of pulmonary artery systolic pressure (PASP) in organic mitral regurgitation (MR) and its prognostic value after surgery.DesignProspective observational study, conducted from 1998 to 2006.SettingEchocardiography and cardiac surgery departments, University Hospital.PatientsEchocardiography was carried out in 256 patients (63+/-12 years, 170 male) with organic MR (degenerative aetiology: 91%) referred for surgery.Main Outcome MeasuresEchocardiography predictors of PASP. Postoperative end points were overall mortality and cardiovascular mortality.ResultsBaseline PASP was 45+/-14 mmHg, ranging from 25 to 105 mmHg. PASP was > or = 50 mmHg in 82 patients (32%). Left atrial volume (p=0.003), mitral deceleration time (p<0.0001) and mitral medial E/E' (p<0.0001) were independent predictors of PASP, whereas left ventricular size and systolic function were not predictors. Mitral valve repair was performed in 194 patients (76%) and mitral valve replacement in 62 (24%). In a Cox model mitral valve repair (HR=0.41 (95% CI 0.20 to 0.85), p=0.016) and PASP (HR=1.43 (95% CI 1.09 to 1.88) per 10 mmHg increment, p=0.011) were independent predictors of overall mortality, even after adjustment for known predictors. PASP (HR=1.49 (95% CI 1.03 to 2.16) per 10 mmHg increment, p=0.033) was also an independent predictor of cardiac mortality. Eight-year survival after surgery was 58.6% and 86.6% in patients with baseline PASP > or = 50 mmHg or <50 mmHg, respectively (p<0.0001).ConclusionsIn organic MR, mitral deceleration time, mitral E/E' and left atrial volume correlate with PASP. Pulmonary artery systolic pressure > or = 50 mmHg is an independent predictor of overall and cardiovascular mortality after surgery in organic MR.

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