• Eur J Cardiothorac Surg · Jun 2011

    Omni-Stat (Chitosan) arrests bleeding in heparinised subjects in vivo: an experimental study in a model of major peripheral vascular injury.

    • Russell W J Millner, Alan S Lockhart, Rebecca Marr, and Keith Jones.
    • Department of Cardiothoracic Surgery, Blackpool Victoria Hospital Whinney Heys Road, Blackpool, FY3 8NR, UK. mr.millner@bfwhospitals.nhs.uk
    • Eur J Cardiothorac Surg. 2011 Jun 1;39(6):952-4.

    ObjectiveTo explore the effectiveness of Omni-Stat (Chitosan) in a model of major haemorrhage in the presence of clotting dysfunction.MethodA total of 12 major femoral artery bleeds in moderately heparinised swine treated with Omni-Stat (Chitosan) were compared with five control bleeds.ResultsHaemostasis was successfully achieved at first treatment in 10 of 12 bleeds and at second treatment in the remaining two bleeds.ConclusionThe study supports the evidence that Omni-Stat (Chitosan) acts independently of classical clotting pathways and should be effective in patients with clotting dysfunctions, who suffer major haemorrhage. It also suggests the potential for a role in cardiac surgery.Copyright © 2010 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…