• Epilepsia · Sep 1987

    Comparative Study

    Observations on the effect of morphine on thalamocortical excitability in the cat.

    • W J Nowack, R N Johnson, and G R Hanna.
    • Department of Neurology, University of Arkansas for Medical Sciences, Little Rock 72205.
    • Epilepsia. 1987 Sep 1;28(5):457-62.

    AbstractThe acute effects of morphine on the thalamocortical augmenting response in the cat were evaluated. The thalamocortical augmenting response was elicited by delivering pairs of pulses to the ventrolateral thalamus and recording from ipsilateral sensorimotor cortex. A biphasic, dose-related, naloxone-attenuable effect on the augmenting response elicited by pulse pairs was observed. Although the clinical significance of those morphine-induced changes is currently uncertain, they can be correlated with the convulsant and anticonvulsant effects of different doses of morphine.

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