• Therapie · Jan 1999

    Review

    [Physiopathology of neuropathic pain syndromes].

    • M Lantéri-Minet.
    • Département d'Evaluation et Traitement de la Douleur, CHU de Nice, Hôpital Pasteur, France.
    • Therapie. 1999 Jan 1;54(1):117-20.

    AbstractThis article reviews the peripheral and central mechanisms of neuropathic pain. The main mechanisms involved in neuropathic pain are: (1) ectopic activities, (2) ephapses, (3) sensitization of nociceptors. Central morphological alterations could also be involved: (1) medullar neuronal reorganization, (2) hyperexcitability of central nervous system nociceptive neurones. The relative resistance of these neuropathic pains to opioid drugs could be related to a decrease in the number of opioid receptors to an amino acid mediator related spinal neurons hyperexitability and to an increase in non opioid peptides such as cholecystokinin.

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