• Pediatr Neonatol · Dec 2011

    Case Reports

    Anti-N-methyl-d-aspartate receptor encephalitis.

    • Te-Yu Hung, Ning-Hui Foo, and Ming-Chi Lai.
    • Department of Pediatrics, Chi-Mei Foundation Hospital, Tainan, Taiwan.
    • Pediatr Neonatol. 2011 Dec 1;52(6):361-4.

    AbstractAnti-N-methyl-d-aspartate (NMDA) receptor encephalitis is a treatment-responsive encephalitis associated with anti-NMDA receptor antibodies, which bind to the NR1/NR2 heteromers of the NMDA receptors. It is a highly characteristic syndrome evolving in five stages: the prodromal phase (viral infection-like symptoms), psychotic phase, unresponsive phase, hyperkinetic phase, and gradual recovery phase. It has been considered as a paraneoplastic syndrome usually affecting childbearing-age female with ovarian tumors; however, recent reports suggest a much higher incidence of nonparaneoplastic cases in children. We report a 14-year-old girl with anti-NMDA receptor encephalitis without a detectable tumor who showed a nearly complete recovery after intensive immunotherapy.Copyright © 2011. Published by Elsevier B.V.

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