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Neuroscience letters · Mar 2000
Inhibition of adjuvant-induced inflammatory hyperalgesia in rats by local injection of neurotrophin-3.
- M Watanabe, Y Endo, K Kimoto, R Katoh-Semba, and Y Arakawa.
- Department of Pharmacy, Branch Hospital, Faculty of Medicine, University of Tokyo, Mejirodai 3-28-6, Bunkyo-ku, Tokyo, Japan.
- Neurosci. Lett. 2000 Mar 17;282(1-2):61-4.
AbstractThe induction of nerve growth factor (NGF) in inflammatory tissue has been shown to be involved in hyperalgesia. In the present study, the role of neurotrophin-3 (NT-3) in the regulation of inflammatory hyperalgesia was analyzed. Inflammatory hyperalgesia was induced by intraplantar injection of complete Freund's adjuvant (CFA) to the rat hind paw. NT-3 levels in the plantar skin were much higher than NGF levels (1.24 and 0.14 ng/g tissue, respectively) before CFA injection, but decreased significantly 6 h to 48 h after the injection while NGF was markedly induced at 6 h but decreased thereafter. When 1 microg of NT-3 was locally injected at 5 h after CFA injection at the time NT-3 levels decreased, hyperalgesia was reversed transiently but specifically. These results suggest an inhibitory role of NT-3 in the regulation of pain sensitivity.
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