• Hypertension · Feb 2015

    Comparative Study

    Maternal diet during gestation and lactation modifies the severity of salt-induced hypertension and renal injury in Dahl salt-sensitive rats.

    • Aron M Geurts, David L Mattson, Pengyuan Liu, Erwin Cabacungan, Meredith M Skelton, Theresa M Kurth, Chun Yang, Bradley T Endres, Jason Klotz, Mingyu Liang, and Allen W Cowley.
    • From the Departments of Physiology (A.M.G., D.L.M., P.L., M.M.S., T.M.K., C.Y., B.T.E., J.K., M.L., A.W.C.), Pediatrics (E.C.), and Cardiovascular Research Center (A.M.G.), Medical College of Wisconsin, Milwaukee. ageurts@mcw.edu.
    • Hypertension. 2015 Feb 1;65(2):447-55.

    AbstractEnvironmental exposure of parents or early in life may affect disease development in adults. We found that hypertension and renal injury induced by a high-salt diet were substantially attenuated in Dahl SS/JrHsdMcwiCrl (SS/Crl) rats that had been maintained for many generations on the grain-based 5L2F diet compared with SS/JrHsdMcwi rats (SS/Mcw) maintained on the casein-based AIN-76A diet (mean arterial pressure, 116±9 versus 154±25 mm Hg; urinary albumin excretion, 23±12 versus 170±80 mg/d). RNAseq analysis of the renal outer medulla identified 129 and 82 genes responding to a high-salt diet uniquely in SS/Mcw and SS/Crl rats, respectively, along with minor genetic differences between the SS substrains. The 129 genes responding to salt in the SS/Mcw strain included numerous genes with homologs associated with hypertension, cardiovascular disease, or renal disease in human. To narrow the critical window of exposure, we performed embryo-transfer experiments in which single-cell embryos from 1 colony (SS/Mcw or SS/Crl) were transferred to surrogate mothers from the other colony, with parents and surrogate mothers maintained on their respective original diet. All offspring were fed the AIN-76A diet after weaning. Salt-induced hypertension and renal injury were substantially exacerbated in rats developed from SS/Crl embryos transferred to SS/Mcw surrogate mothers. Conversely, salt-induced hypertension and renal injury were significantly attenuated in rats developed from SS/Mcw embryos transferred to SS/Crl surrogate mothers. Together, the data suggest that maternal diet during the gestational-lactational period has substantial effects on the development of salt-induced hypertension and renal injury in adult SS rats.© 2014 American Heart Association, Inc.

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