• J Cardiovasc Magn Reson · Jan 2005

    Case Reports

    Functional and metabolic recovery of the right ventricle during Bosentan therapy in idiopathic pulmonary arterial hypertension.

    • Matthias Spindler, Michael Schmidt, Oliver Geier, Jörn Sandstede, Dietbert Hahn, Georg Ertl, and Meinrad Beer.
    • Department Internal Medicine I/Center of Cardiovascular Medicine, University Würzburg, Würzburg, Germany. spindler_m@medizin.uni-wuerzburg.de
    • J Cardiovasc Magn Reson. 2005 Jan 1;7(5):853-4.

    AbstractAn impaired high-energy phosphate metabolism might play a critical role in the pathogenesis of right ventricular (RV) failure due to chronic pulmonary arterial hypertension (PAH). 31P-NMR spectroscopy is well established for measurements of high-energy phosphate metabolites in various left ventricular heart diseases, however, mainly for technical and sensitivity reasons, its successful transfer for measurements in the RV is currently missing. In the present study, the usefulness of this non-invasive approach is not only shown in RV failure due to PAH but also tested during subsequent therapy.

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