• Int J Gynaecol Obstet · Jan 2006

    Randomized Controlled Trial

    Oral misoprostol in the third stage of labor.

    • E S Zachariah, M Naidu, and L Seshadri.
    • Department of Obstetrics and Gynecology, Christian Medical College Hospital, Vellore, India.
    • Int J Gynaecol Obstet. 2006 Jan 1;92(1):23-6.

    ObjectiveTo compare the efficacy of intravenous ergometrine, intramuscular oxytocin, and oral misoprostol in the control of postpartum hemorrhage.MethodsMean blood loss, rates of blood loss between 500 and 1000 ml, hematocrit fall greater than 10%, and need for additional oxytocic agents and nature and rates of adverse effects were assessed in this prospective, randomized, controlled study.ResultsAll outcomes were similar in the 3 groups. The main adverse effects in the misoprostol group were temperatures higher than 99 degrees F, which normalized within 2 h and shivering, which was mild and self-limiting.ConclusionsOral misoprostol is as effective as conventional oxytocic agents in preventing postpartum hemorrhage and can be recommended for use in low-resource settings.

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