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Scand. J. Clin. Lab. Invest. · Nov 1998
Thrombin-antithrombin III and D-dimer plasma levels in patients with benign or malignant ovarian tumours.
- M den Ouden, J M Ubachs, J E Stoot, and J W van Wersch.
- Department of Gynaecology, Atrium Medical Centre, Heerlen, The Netherlands.
- Scand. J. Clin. Lab. Invest. 1998 Nov 1;58(7):555-9.
AbstractIn 50 patients with benign ovarian tumours, 39 malignant ovarian carcinoma patients and 39 age-matched healthy women, plasma levels of thrombin-antithrombin III complex and D-dimer were determined as well as CA 125. The coagulation activation marker thrombin-antithrombin III complex and D-dimer levels were elevated in the malignant group compared to the benign and control groups. The results suggest that coagulation and fibrinolysis must play a prominent role in ovarian cancer. Moreover, D-dimer and thrombin-antithrombin III were equally useful as CA 125 for the discrimination of patients with benign or malignant ovarian tumours as evidenced by receiver operating and likelihood ratio calculations.
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