• Melissa L McCarthy, Ellen J MacKenzie, Dennis R Durbin, Mary E Aitken, Kenneth M Jaffe, Charles N Paidas, Beth S Slomine, Andrea M Dorsch, James R Christensen, Ru Ding, and Children's Health After Trauma Study Group.
• Department of Emergency Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA. mmccarth@jhmi.edu
• Arch Pediat Adol Med. 2006 Mar 1;160(3):252-60.

ObjectivesTo document health-related quality of life (HRQOL) of children with traumatic brain injury (TBI) and to examine the relationship between TBI severity and HRQOL during the first year after injury.DesignProspective cohort study.SettingFour pediatric level I trauma centers.PatientsChildren with TBI (n = 330).Main ExposureTraumatic brain injury.Main Outcome MeasuresA primary caregiver completed telephone interviews at baseline, 3 months, and 12 months to measure the child's HRQOL using the Pediatric Quality of Life Inventory. The HRQOL outcomes were modeled as a function of injury, patient characteristics, and family characteristics using longitudinal, multivariable regression.ResultsA considerable proportion of children had impaired HRQOL at 3 months (42% of children) and 12 months (40% of children) after injury. Multiple dimensions of HRQOL were negatively affected among children with moderate or severe TBI (decrease of 3.7 to 17.6) (P<.05) and did not improve significantly over time. Concomitant lower extremity fractures and spinal injuries resulted in large declines in overall HRQOL, particularly at 3 months after injury (decrease of 12.9 and 8.1, respectively) (P<.05). The HRQOL scores were also reduced by preexisting psychosocial conditions (decrease of 2.9 to 12.3), impaired family functioning (decrease of 5.1 to 6.8), having Medicaid coverage or being uninsured (decrease of 3.1 to 5.5), and single-parent households (decrease of 3.2 to 3.4) (P<.05).ConclusionsModerate or severe TBI resulted in measurable declines in children's HRQOL after injury. Injury-related factors impacted HRQOL more compared with patient and family characteristics during the first year after injury.

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